Some migraines can be treated with over-the-counter medications such as ibuprofen, acetaminophen or aspirin, if taken at the first signs of a migraine occurring. When these aren't effective, the most commonly prescribed treatment is a class of drugs called triptans, which are considered more effective than ubrogepant but have a catch: They work by constricting blood vessels around the brain to stop the pain, so they are not considered safe for use by people at risk of cardiovascular disease and stroke. The newly approved drug, on the other hand, has a different molecular target -- a protein involved in the transmission of pain.
Bempedoic acid is a once-a-day oral medication that will be commercially known as Nexletol. The FDA approved it for use with a healthy diet and the maximum dose of statins a patient tolerates. Studies show the new drug can reduce what doctors call low-density lipoprotein cholesterol, what you may know as LDL, the "bad" cholesterol that can lead to heart problems or strokes.